Comparison with the Cardiac Lesions of Serum Disease

In a previous communicat ion (1) we presented da ta indicat ing tha t cardiac lesions, closely resembling those characteris t ic of rheumatic fever in man, had been induced in a small propor t ion of rabbi ts t ha t had undergone mult iple , successive skin infections with group A streptococci of several serological types. How the hypothesis leading to those experiments evolved is described elsewhere (2). The purpose of this repor t is to submit addi t ional examples of the rabb i t cardiac lesions, together with representat ive human cardiac lesions from several fa tal cases of act ive rheumatic fever; to describe them and their apparen t evolution; and to compare and characterize the two groups, both as to their morphology and pathogenesis.